Endocrine Abstracts

Brown tumors (BT) consist of focal bone lesions, caused by increased osteoclastic activity and fibroblastic proliferation. They appear in chronic kidney disease (CKD) as a result of renal osteodystrophy with high bone turnover, due to secondary hyperparathyroidism. BT are composed of mononuclear stromal cells mixed with multinucleated giant cells and hemosiderin deposits, which give the characteristic brown colour. We present the case of a 13-year-old girl, with end-stage CKD ...

IntroductionMayer-Rokitansky-Küster-Hauser (MRKH) type 2 or MURCS (Müllerian duct aplasia, unilateral renal agenesis and cervicothoracic somite anomalies) syndrome is a congenital disease with an incidence of 1 in 4000–5000 female live births, with unknown etiology. Several chromosomal abnormalities were associated with the disease, with a normal 46XX karyotype and familial members to share the same associated anomalies as sporadic cases h...